After Installation of Oracle Client 32Bit version on Windows 2008 R2 64Bit version, when I tried to connect to Oracle using TOAD it gave an error ORA-06413 - Connection Not Open on the same system.
I found Cause for this problem : TOAD Was installed in Program Files(86)
I found Solution for this: I installed TOAD into QUEST folder in C: drive and it worked.
Other Hint - .Net application also was having same problem in establishing connection with Oracle on Windows 2008 R2 64 bit version. So, I installed .Net in folder other than default location "Program Files(86)" and it worked.
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